GM- Downstream Current
Four named strains
40 billion CFU
Vegan capsules
Your result · Type GM
Start upstream. The rest is downstream of it.
The gut went first. The weight came after. Most advice you have been given works on the second one.
The order is the whole point of this result. Where your hormones get processed sits upstream of how your body handles fuel, which is why working only on the food has not moved anything.
+ Supports a healthy gut microbiome
+ Supports the body’s normal estrogen metabolism
+ Supports a healthy metabolism
+ Supports how the body handles blood sugar
+ Four named strains, 40 billion CFU
+ One protocol, once a day
What is actually going on.
As estrogen drops through your forties, an enzyme called CD38 speeds up. CD38 burns through NAD+, the fuel your cells use to make energy and repair themselves.
Less NAD+ shows up first where you feel it most: your gut, and then your metabolism. That is why your result is GM.
Your NAD+ levelBefore 40
Estrogen keeps CD38 in check. Your cells have the fuel they need.
Estrogen ↓
drops in your 40s
→
CD38 ↑
enzyme speeds up
→
NAD+ ↓
cell fuel runs low
→
Gut + metabolism
where you feel it
2021
Published in ScienceA randomized, placebo-controlled trial studied NMN for its role in raising NAD+ and improving insulin sensitivity in women after menopause.1
NMN
0 mg
Probiotic 40B
0 billion CFU
Berberine
0 mg
Three compounds · three jobs · one protocol
What is in one daily serving.
Most supplements give you one ingredient. The Downstream Current works on the full GM pattern: refill the fuel, rebuild the estrobolome upstream, support the metabolic switch downstream.
No proprietary blends. Every amount is printed, because a blend that hides its doses is usually hiding how little is in it.
NMN
500 mg
Refills the fuel your cells run on.
Probiotic 40B
40 billion CFU
Supports a balanced gut microbiome.
Berberine
800 mg
Supports how your body handles blood sugar.
Your pattern, traced
Why the same things stopped working.
GM is two systems running off one shortage. Tap what you have noticed and follow it back.
You notice
→
What is happening underneath
→
In the protocol for it
Descriptions of biological mechanisms studied in the literature. Not a claim to treat, cure or prevent any condition.
The gut arm, upstream
The estrobolome is the community of gut bacteria involved in estrogen metabolism, working partly through beta-glucuronidase activity. This is where the sequence starts.
Probiotic 40 BillionFour named strains: L. Acidophilus, B. Lactis, L. Plantarum and L. Paracasei, with a fructooligosaccharide prebiotic.
The metabolic arm, downstream
Insulin signalling shifts as estrogen availability changes, which is why the metabolic symptoms arrived after the gut ones rather than alongside them.
Berberine 800 mgStudied for its role in activating AMPK, an enzyme involved in how cells take up and use glucose.
The shared root
Estrogen falls, CD38 rises, and NAD+ gets consumed. Both ends of the current run off that same shortage.
NMN 500 mgA direct precursor to NAD+.
No magic pill. The honest version.
Day 1
Start simple.One serving a day, with or without food.
Weeks 1–4
Consistency does the work.NAD+ support is about showing up daily, not one big dose.
Ongoing
A standing routine.Built to lean on through the transition, not a quick fix.
Not the same as another probiotic.
The Downstream Current
Typical supplement
+Three named compounds, three doses
×One ingredient, or a hidden blend
+Doses printed on the label
דProprietary blend,” amounts hidden
+Matched to your GM result
×One size fits all
+One daily protocol
×A shelf of separate bottles
Early reviewers
What came back.
We asked the first women on the protocol one question: did anything feel different?
★★★★★
“I have tried a lot of things over the last few years. This is the one I kept taking.”
Linda C. · early reviewer
Received the protocol at no cost
Received the protocol at no cost
★★★★★
“I used to graze my way through every stressful afternoon. That quieted down. I stopped feeling like I was negotiating with myself all day.”
Jane B. · early reviewer
Received the protocol at no cost
Received the protocol at no cost
★★★★★
“Nothing dramatic. Just steadier. Which is exactly what I was hoping for.”
Violet S. · early reviewer
Received the protocol at no cost
Received the protocol at no cost
Early reviewers include friends and colleagues of the founders and received the protocol at no cost. Their reviews are their own. Individual results vary.
Feel like yourself again.
The Downstream Current
$81.75$109/mo
Subscribe & save 25% · $81.75/mo
Order once · $109
The 60-Day Promise: give it a full 60 days. If it is not for you, request a full refund any time between day 60 and day 90.
25% off applies to every order, including your first. Ships every 30 days, cancel anytime. These statements have not been evaluated by the Food and Drug Administration. This product is a dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease. Individual results vary.
Quick questions.
Is this just NMN?
No. NMN refills the fuel. Probiotic 40 Billion works on the upstream gut side. Berberine works on the downstream metabolic side. Three jobs, not one.
Why show the doses?
NMN and Berberine carry printed doses, 500mg and 800mg. The probiotic lists four named strains and 40 billion CFU, though the manufacturer does not publish the split between individual strains. We would rather tell you that than pretend otherwise.
When can I use the guarantee?
After a full 60 days of daily use, and up to day 90. That window gives the protocol a fair run before you decide.
Is it vegan?
Yes. All three use plant-based capsules: NMN in HPMC, the probiotic in hypromellose, Berberine in cellulose. No gelatin in this protocol.
Can I take it with my medication?
Talk to your clinician first, especially if you take medication for blood sugar or are immunocompromised. This is a supplement, meant to sit alongside your care, not replace it.
The Downstream Current$81.75/mo · 25% off, first order too
Start now